AUTOLOGOUS MSCS VS ALLOGENEIC MSCs
Autologous stem cells are stem cells that are derived from the patients themselves who are undergoing therapy. An example would be using the patient’s own stem cells derived from the patient’s fat.
What are Allogeneic Stem Cells?
Allogeneic Stem cells are stem cells that are derived from a donor to be used in therapy and hence, not derived from the patient undergoing therapy. Stem cells harvested and cryopreserved from these donors are revived and administered into the patient. An example would include human umbilical cord stem cells.
What we offer?
We offer Allogeneic stem cells derived from the Wharton’s Jelly of the human umbilical cord and human deciduous dental pulp
Why do we offer Allogeneic stem cells?
- Age of donor Stem cells are more potent and have better differentiation potential when the donors of the stem cells are very young.
- Standardized predictable outcome We have established standard protocols to:
Our clients or patients tend to be above 30 years of age (mostly in the above 40 category). This means that their cells do not have the same regenerative ability that they once did when the client/patient was young.
The cells in the human umbilical cord are the same age as a new-born baby. Therefore, their ability to regenerate tissue is much stronger. The client/patient would get the youngest possible.
Since human MSCs are immunoprivileged, they will not elicit an immune response when injected into another person and there will be no rejection.
- Screen the donors to ensure they are free from infectious diseases and safe to be used
- Isolate, harvest, cryopreserve and revive the stem cells.
- Screen the cells to ensure they are safe for delivery
- An extensive screening process for the donors
- Establishing a new protocol for isolation, harvesting, cryopreserving and reviving the cells since the cells are different. This would take a lot of time devising, testing and then implementing said protocol
- Screening the cells again to ensure they are safe for delivery
In the case of fat stem cells from the own patient, there is the added complexity of how much body fat does the patient have. Using fat cells would require ample amounts of fat, which can only be possible in overweight patients and it would also require surgery to remove that fat. And then we will have to screen the fat cells to ensure if they can be used, and if they are not viable, then the surgery would have been a waste of time and money for the client/patient. Using our allogeneic stem cells would not require any surgery to obtain the cells and there is already an established protocol with a standardized predictable outcome.
WHAT IS PASSAGE AND WHY IS EARLY PASSAGE IMPORTANT FOR MSCs?
Early passages are better for stem cell therapy. Cells from higher passage number may alter MSCs potency and efficacy. Studies have shown that early passage number was associated with better therapeutic outcomes. The 1-year survival and response rate in those who received low passage MSCs were 75% and 86%. Whereas those who received high-passage MSCs showed a lower 1-year survival and response rate at 21% and 36% respectively.
*Source: Nitkin, C. R. and Bonfield, T. L. (2017). Concise Review: Mesenchymal Stem Cell Therapy for Pediatric Disease: Perspectives on Success and Potential Improvements. Stem Cells Transl Med. 6(2): 539-565
HOW DO STEM CELLS WORK?
The most commonly known role of stem cells is their ability to develop into different organs but they also have other properties that can be very important for healing. Stem cells produce over 30 kinds of growth factors and tissue chemicals that initiate the healing process in the body. Stem cells help assemble other local and systemic mesenchymal stem cells to focus on repairing damaged tissue and organs. They are also active in immune modulation to support or suppress T-cell work in the body.
Stem cells are stimulated to travel into an area by signals from the organ depending on chemical, neural and mechanical properties.
Under ideal conditions mesenchymal stem cells would respond to damages and healing would occur. Factors that affect stem cell response include fitness of the patient, age, and the level of free radicals in the body.
5 WAYS HOW MSCs WORK
*Source: Spees, J.L., Lee, R.H. and Gregory, C.A. (2016). Mechanism of Mesenchymal Stem/Stromal Cell Function. Stem Cell Res Ther. 7(1): 125.
HOW DO I RECEIVE THE STEM CELLS?
Our therapy uses stem cell injections. Every patient has distinct requirements for stem cell injections and upon consultation, a custom stem cell therapy program will be designed for each individual specifically. The program will include information on the administering process, selected routes and number of stem cells to be injected. Depending on each case, stem cells can be:
- Injected locally (e.g., osteoarthritis)
- Intravenous injection (e.g., general wellness)
- Intrathecal injection (e.g., spinal cord injury/Traumatic Brain Injury)
WHAT ARE THE BENEFITS OF STEM CELL THERAPY?
- Potential to reverse diseases: Stem cell therapy offers a better alternative for many diseases like Parkinson’s, stroke and autism. Many diseases that were hard to treat in the past can now be improved using stem cell therapy.
- Speeds up healing: Stem cell therapy has been found to reduce the length of time it takes for injuries to heal.
- Reduces pain: It’s less painful to treat conditions such as chronic joint pain using stem cells.
- Increases functionality: Stem cell therapy also increases flexibility and range of motion when used to treat joint pain.
- Reduce risk of injury: Stem cell studies have shown that the therapy reduces muscle compensations as well as the risk of injuries in the future.
- Reduced over-dependence on conventional medicine.
WHAT ARE THE RISKS OF STEM CELL THERAPY?
Mesenchymal stem cell therapy is considered safe and effective. However, there is still a lot of ongoing research in the field. Hence, therapy should be confined to conditions where there is scientific evidence from reputable and peer-reviewed sources that shows the potential for MSCs to help in improving the condition. As a precaution, you must seek treatment from qualified medical practitioners only. This precaution is important given the existence of many unscrupulous medical practitioners who aren’t qualified to offer stem cell therapies.
Source: Zhao, Q., Ren, H., & Han, Z. (2016). Mesenchymal stem cells: Immunomodulatory capability and clinical potential in immune diseases. Journal of Cellular Immunotherapy, 2(1), 3-20. doi:10.1016/j.jocit.2014.12.001
All our stem cells are obtained from ethical sources. We provide stem cells at passage 2 (premium quality) for better results. Our donors are screened for infectious diseases and the cells are cultured in a sterile environment. Every batch of the cultured MSCs is tested for mycoplasma contamination and harmful bacterial toxins and MSC characterization i.e. Immunophenotyping, Trilineage differentiation and Morphology abnormality, before approval for clinical usage.
All critical equipment involved in the cell manufacturing process are in-vitro diagnostic (IVD) grade and calibrated annually (ISO 17025 standard) according to the International Society for Cell& Gene Therapy (ISCT).
We are the manufacturers of stem cells. We get the therapy direct from the source to the client with no middle-man.